| Januari: | ||
| 8 | Michelle Forbes (Special Agent Samantha Brinker) | 1965 |
| 11 | Rockmond Dunbar (Benjamin ‘C-Note’ Miles Franklin) | 1973 |
| Februari | ||
| 17 | Dominic Purcell (Lincoln Burrows) | 1970 |
| Maart: | ||
| 7 | John Heard (Gouverneur Frank Tancredi) |
1945 |
| 8 | Barbara Eve Harris (FBI agent Lang) | 1959 |
| 28 | Brett Ratner (uitvoerend producent) | 1969 |
| April: | ||
| 5 | Marshall Allman (LJ Burrows) |
1984 |
| 29 | Paul Adelstein (Paul Kellerman) | 1969 |
| Mei: | ||
| 11 | Kristin Lehman (Jane Phillips) | 1970 |
| 11 | Holly Valance (Nika Volek) | 1983 |
| 23 | Lane Garrison (David ‘Tweener’ Apolskis) | 1980 |
| Juni: | ||
| 1 | Sarah Wayne Callies (Sara Tancredi) | 1977 |
| 2 | Wentworth Miller (Michael Scofield) |
1972 |
| 2 | Stacy Keach (Warden Henry Pope) | 1941 |
| 8 | Frank Grillo (Nick Savrinn) | 1963 |
| 19 | Robin Tunney (Veronica Donovan) | 1972 |
| 28 | camille Guaty (Maricruz Delgado) | 1978 |
| Juli: | ||
| 8 | Robert Knepper (T-Bag) | 1959 |
| 20 | Muse Watson (Charles ‘DB Cooper’ Westmoreland) | 1948 |
| Augustus: | ||
| 16 | Jeff Perry (Terrence Steadman) | 1955 |
| 27 | Peter Stormare (John Abruzzi) | 1953 |
| September: | ||
| 14 | Robert Wisdom (Lechero) | 1953 |
| Oktober: | ||
| 3 | Carlo Alban (McGrady) | |
| 10 | Jodi Lyn O'Keefe (Susan B. Anthony) | 1978 |
| 16 | Christian Stolte (C.O. Keith Stolte) | 1962 |
| 18 | Kurt Caceres (Hector Avila) | 1972 |
| 24 | Mark Morettini (C.O. Rizzo Green) | 1962 |
| November: | ||
| 20 | Callie Thorne (Pam Mahone) | 1969 |
| 27 | William Fichtner (Alexander Mahone) | 1956 |
| December: | ||
| 1 | Chris Vance (James Whistler) | 1971 |
| 4 | Patricia Wettig (President Caroline Reynolds) | 1951 |
| 6 | Leon Russom (Pad Man) | 1941 |
| 24 | Amaury Nolasco (Fernando Sucre) | 1970 |
| 24 | Wade Williams (Brad Bellick) | 1961 |